What Does A Low and High GGT Test Mean ?

GGT, one of the Blood tests, gets its name from the abbreviation of “Gamma Glutamyl Transferase” and is commonly used to diagnose Liver and Pancreatic Diseases.

What is GGT ?

GGT is an enzyme mainly found in the Liver, Kidney and Pancreas.

Although not as much as ALT and AST, it is a very desirable test for diagnosis and follow-up of Liver Diseases.

It is usually desirable to see Liver Functions and to investigate Alcoholic Liver Disease.

GGT is a good marker to see whether Alcohol quitting in Alcoholism or whether it has been restarted, especially in Chronic Alcoholics.

When the GGT / ALP ratio is > 5, the likelihood of Alcoholic Liver Disease is very high.

GGT levels return to normal after 1 month of Alcohol abuse.

GGT levels usually do not increase in Bone diseases, Pregnancy and Muscle Diseases.



What Does GGT Elevation Mean in a Blood Test ?

The GGT elevation can be seen in the following situations;

Liver Diseases (Hepatitis, Cirrhosis, Metastases, Cholestasis …)


Kidney Diseases (due to improper GGT clearance)

Smoking (10% increase in 1 package per day)

Black African men (about 2 times higher)


Infectious Mononucleosis (EBV, a viral disease)


Prostate Cancer

Breast-Lung-Colon Cancer


Glycogen Storage Disease


Drugs (antibiotics, anti-inflammatories, phenytoin, phenobarbital, carbamazepine, cimetidine, furosemide, heparin, isotretinoin, methotrexate, valproic acid ..)

What Does Low GGT Levels Mean in Blood Test ?

Low GGT levels is not used very often in the diagnosis, so if GGT is low this is not considered too much but it can be seen in the following situations;


Early Pregnancy Period

Drugs (azathioprine, ursodiol, oral contraceptives, clofibrate)

How is GGT Test Done ?

Blood from your pouch is placed on a scaffold and serum is separated, this serum is administered to the device called Biochemistry Autoanalyzer.

Alcohol should not be taken until 24 hours before blood is given.

What Are The Normal (Reference) Values ​​for GGT ?

The reference intervals vary depending on the device used in each laboratory, the kit, the age of the person, and the gender.

For this reason, the reference values ​​given in each laboratory may show slight variations.

Nevertheless, it is almost calm;

Males: 7 – 47 U/L

Females: it should be between 5 – 25 U/L.



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